Target protection as a key antibiotic resistance mechanism

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed b...

Antibiotic overuse: a key driver of antimicrobial resistance.

Granulation as a Privacy Protection Mechanism

How to achieve a balance between data publication and privacy protection has been an important issue in information security for several years. When microdata is released to users, attributes that clearly identify individuals are usually removed. Nevertheless, it is still possible to link released data with some public or easy-to-access databases to obtain confidential information. To safeguard...

The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae.

OBJECTIVES Alterations in the PhoPQ two-component regulatory system may be associated with colistin resistance in Klebsiella pneumoniae. MgrB is a small transmembrane protein produced upon activation of the PhoPQ signalling system, and acts as a negative regulator on this system. We investigated the role of the MgrB protein as a source of colistin resistance in a series of K. pneumoniae. METH...

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection.

Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which these proteins act has been a subject of long-standing controversy, with two competing hypotheses each having gained considerable support: antibiotic efflux versus ribosomal prot...